In a terrible car accident, Lori Coble and her husband lost all three of their children. After supporting one another through an unfathomable sorrow, the couple used IVF to create a second set of triplets years later. Lori has now revealed the devastating news that she has been given a Stage 4 brain cancer diagnosis.
No one should ever have to go through what Lori Coble and her husband, Chris, went through in May 2007. On May 4, a large rig struck the rear of her minivan while she was motionless in highway traffic.
The three children of Lori and Chris—Kyle Christopher, age five; Emma Lynn, age four; and Katie Gene, age two—were in the vehicle. Life would never be the same after the crash, and none of the kids survived.
Lori was hurt, and the kids were sent to various hospitals. Before Lori woke up, Emma and Katie passed away. It was too late when Chris hurried Lori to the hospital where Kyle was receiving treatment.
In an interview with Oprah, Chris recounted, “She’s climbing out of the wheelchair as best she can to hug Kyle and saying: ‘He’s got to go be with his sisters now.” His sisters are anticipating his arrival.
“After we turned off life support, the room and the machines went dark. Until his heart stopped beating, I kept my hand on his chest. He said, “And he was gone.”
Following the deaths of their children in a vehicle accident, Lori Coble and her husband Chris welcomed triplets.
Lori made a deal with her husband. They agreed that they would not end their lives, even if they felt that there was no use in living, and instead would provide each other with unwavering support during the traumatic event.
They yearned to be parents once more as they grieved for their kids. They pursued IVF even though Chris had undergone a vasectomy. Soon after, they discovered three live embryos, which resembled their three late children: two girls and one boy.
Chris and Lori welcomed their triplets a year after Kyle’s death, and Emma and Katie died as well.
It took me more than four years to recover from the agony and confusion of what had transpired. Chris told People Magazine that during the first three years of raising the triplets, he experienced a mixture of happiness and joy, but he was also in internal sorrow.
“These three babies are all quite happy. However, I was attempting to keep myself from crumbling in front of them; I would quickly cry in the other room before returning to put a smile on my face.
Becky Leonard, a family friend, described Lori as “extraordinary — everybody who knows her, loves her.” She is a mother first and foremost.
It’s difficult to describe what the Coble family has gone through. And now there’s even more heartache. Chris observed that Lori was “getting more clumsy” in June 2025 because she frequently dropped glasses on the ground, stubbed her toes on furniture, and so forth.
Lori was given a stage 4 brain cancer diagnosis.
A few weeks later, he saw that her “mouth started to droop a little bit,” which was a sign of stroke-like symptoms. “Too much to ignore” was the term used.
Lori Coble was diagnosed with a big, extremely aggressive stage 4 glioblastoma, or brain cancer, in the middle of July.
Chris told People, “I was hoping we were done with the life-altering, life-changing disasters where life as you knew it yesterday is gone.”
Since then, Lori has had both good and bad outcomes from her treatment. Her brain was found to have a significant infection in mid-November, necessitating more surgery.
According to Chris, Lori’s cognitive abilities have improved recently, and the infection is getting better. The family has decided to bring her home for hospice care because she has said that she does not want any more surgery.
Becky Leonard, a family friend, said, “We are thankful they can create a more advanced hospital space in the house because she wants to be at home with the family and dogs.”
“My wife is no longer who I knew her to be.”
To assist cover the roughly $30,000 monthly cost of home health care, Chris Coble has created a GoFundMe page. Since September, he has taken an unpaid leave of absence.
“My wife is no longer the person I knew, and I don’t think she will ever return to her former self,” he says. “She’s been repeatedly punched when she’s down throughout everything she’s been through. It’s incredible that she is still alive. She has endured a great deal.
The family has raised almost $278,000 as of this writing.
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